New model of Oral Mucositis with 5-Fluorouracil chemo-induced in Wistar rats without the use of anesthesics
ABSTRACT Introduction: Oral mucositis (OM) is considered the most frequent acute side effect of the antineoplasic treatment, with ulcerative lesions resulting from a painful symptomatology, affecting the oral cavity in response to the Antineoplastic treatment.In order to study these side effects, experiments in animal models are necessary, using an